• Chang-Yang Xing, Takashi Tarumi, Rutger L Meijers, Marcel Turner, Justin Repshas, Li Xiong, Kan Ding, Wanpen Vongpatanasin, Li-Jun Yuan, and Rong Zhang.
• From the Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas (C.-Y.X., T.T., R.L.M., M.T., J.R., R.Z.); Department of Internal Medicine (C.-Y.X., W.V., R.Z.) and Department of Neurology and Neurotherapeutics (T.T., K.D., R.Z.), University of Texas Southwestern Medical Center, Dallas; Department of Ultrasound Diagnostics, Tangdu Hospital, Fourth Military Medical University, Xi'an, China (C.-Y.X., L.-J.Y.); Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, The Netherlands (R.L.M.); and Department of Medicine and Therapeutics, Chinese University of Hong Kong, China (L.X.).
• Hypertension. 2017 Apr 1; 69 (4): 712-720.

AbstractAge-related alterations in systemic and cerebral hemodynamics are not well understood. The purpose of this study is to characterize age-related alterations in beat-to-beat oscillations in arterial blood pressure (BP), heart rate (HR), cerebral blood flow (CBF), cardiac baroreflex sensitivity, and dynamic cerebral autoregulation across the adult life span. We studied 136 healthy adults aged 21 to 80 years (60% women). Beat-to-beat BP, HR, and CBF velocity were measured at rest and during sit-stand maneuvers to mimic effects of postural changes on BP and CBF. Transfer function analysis was used to assess baroreflex sensitivity and dynamic cerebral autoregulation. Carotid-femoral pulse wave velocity was measured to assess central arterial stiffness. Advanced aging was associated with elevated carotid-femoral pulse wave velocity, systolic and pulse BP, cerebrovascular resistance, and CBF pulsatility, but reduced mean CBF velocity. Compared with the young and middle-aged, older adults had lower beat-to-beat BP, HR, and CBF variability in the low-frequency ranges at rest, but higher BP and CBF variability during sit-stand maneuvers. Baroreflex sensitivity was reduced, whereas dynamic cerebral autoregulation gain was elevated at rest in older adults. Multiple linear regression analysis indicated that systolic BP variability is correlated positively with carotid-femoral pulse wave velocity independent of HR variability. In conclusion, advanced aging is associated with elevated pulsatility in BP and CBF; reduced beat-to-beat low-frequency oscillations in BP, HR, and CBF; and impaired baroreflex sensitivity and dynamic cerebral autoregulation at rest. The augmented BP and CBF variability in older adults during sit-stand maneuvers indicate diminished cardiovascular regulatory capability and increased hemodynamic stress on the cerebral circulation with aging.© 2017 American Heart Association, Inc.

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