• Ann. Intern. Med. · Aug 2021

    Serial SARS-CoV-2 Receptor-Binding Domain Antibody Responses in Patients Receiving Dialysis.

    • Shuchi Anand, Maria E Montez-Rath, Jialin Han, Pablo Garcia, LinaCel Cadden, Patti Hunsader, Russell Kerschmann, Paul Beyer, Scott D Boyd, Glenn M Chertow, and Julie Parsonnet.
    • Stanford University, Stanford, California (S.A., J.P.).
    • Ann. Intern. Med. 2021 Aug 1; 174 (8): 1073-1080.

    BackgroundAssessing the evolution of SARS-CoV-2 immune response among patients receiving dialysis can define its durability in a highly clinically relevant context because patients receiving dialysis share the characteristics of persons most susceptible to SARS-CoV-2 infection.ObjectiveTo evaluate the persistence of SARS-CoV-2 receptor-binding domain (RBD) IgG in seroprevalent patients receiving dialysis.DesignProspective.SettingNationwide sample from dialysis facilities.Patients2215 patients receiving dialysis who had evidence of SARS-CoV-2 infection as of July 2020.MeasurementsRemainder plasma from routine monthly laboratories was used to measure semiquantitative RBD IgG index value over 6 months.ResultsA total of 2063 (93%) seroprevalent patients reached an assay detectable response (IgG index value ≥1). Most (n = 1323, 60%) had responses in July with index values classified as high (IgG ≥10); 1003 (76%) remained within this stratum. Adjusted median index values declined slowly but continuously (July vs. December values were 21 vs. 13; P < 0.001). The trajectory of the response did not vary by age group, sex, race/ethnicity, or diabetes status. Patients without an assay detectable response (n = 137) were more likely to be White and in the younger (18 to 44 years) or older (≥80 years) age groups and less likely to have diabetes and hypoalbuminemia.LimitationLack of data on symptoms or reverse transcriptase polymerase chain reaction diagnosis, cohort of persons who survived infection, and use of a semiquantitative assay.ConclusionDespite impaired immunity, most seropositive patients receiving dialysis maintained RBD antibody levels over 6 months. A slow and continual decline in median antibody levels over time was seen, but no indication that subgroups with impaired immunity had a shorter-lived humoral response was found.Primary Funding SourceAscend Clinical Laboratories.

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