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Journal of hepatology · May 1992
Case ReportsLiver damage from flucloxacillin, cloxacillin and dicloxacillin.
- R Olsson, B E Wiholm, C Sand, L Zettergren, R Hultcrantz, and M Myrhed.
- Department of Medicine II, University of Gothenburg, Sweden.
- J. Hepatol. 1992 May 1; 15 (1-2): 154-61.
AbstractWe describe a case of severe cholestatic liver disease, which persisted for 7 years, and was probably induced by flucloxacillin. We also report a survey of 77 liver reactions which were probably or possibly induced by penicillinase-resistant penicillins and spontaneously reported to the Swedish Adverse Drug Reactions Advisory Committee. The reactions were usually cholestatic with a tendency to a protracted course. There is some evidence for an immunoallergic idiosyncratic reaction. The incidence of reported liver reactions was estimated from sales data to be 1.6-2.9 per million DDD (defined daily doses) or, for flucloxacillin 1:11,000-1:30,000 prescriptions. Female sex, age and high daily doses seemed to be associated with higher risk of liver reactions from flucloxacillin.
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