• Carla Bastida, Maria Antonia Also, Juan Manuel Pericas, Emili Letang, Montse Tuset, and Josep Maria Miró.
• Servicio de Farmacia, Hospital Clínic, Barcelona, España. Electronic address: cbastida@clinic.ub.es.
• Enferm. Infecc. Microbiol. Clin. 2014 Nov 1; 32 (9): 579-82.

IntroductionDrugs like statins may induce rhabdomyolysis. Simvastatin and lovastatin have a high hepatic metabolism and their potential toxicity could be increased by interactions with other drugs that reduce their metabolism.Patients And MethodsA case-report is presented of an HIV-infected patient treated with antiretroviral drugs who developed a rhabdomyolysis-induced renal failure and liver toxicity when simvastatin was substituted for atorvastatin. A literature review is also presented.ResultsThe patient required hospital admission and showed a favorable response after hydration and urine alkalinization. There were 4 additional cases published of which there was one death.ConclusionsDrug-drug interactions can increase the risk of statin induced rhabdomyolysis. In order to evaluate them properly, physicians at all levels of clinical care should be aware of all drugs prescribed to their patients and the contraindicated combinations.Copyright © 2014 Elsevier España, S.L.U. y Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica. All rights reserved.

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