• Ling-Ying Niu, Jian-Feng Gong, Xiao-Wei Wei, Wei-Ming Zhu, Ning Li, and Jie-Shou Li.
• Research Institute of General Surgery, Clinical School of Medical College of Nanjing University, Nanjing General Hospital of Nanjing Military Command, Nanjing 210002, China.
• Zhonghua Wai Ke Za Zhi. 2009 Feb 15; 47 (4): 275-8.

ObjectiveTo observe the efficacy of perioperative combined nutritional support in patients with Crohn disease.MethodsFrom January 2000 to June 2008, 165 patients with Crohn disease receiving perioperative nutritional support were included in this retrospective analysis. The patients were divided into three groups according to the ways of nutritional support: total enteral nutrition group, total parenteral nutrition group and combined nutrition group; there were 55 patients in each group. Each group had the same treatment except for nutritional support. The efficacy of different approaches of nutritional support was analyzed and compared among the groups.ResultsCompared with total enteral and total parenteral nutrition, combined nutrition supplied more sufficient energy, the nutritional status improved more significant in short time; pre-albumin, transferrin, lymphocytes and platelet count increased significantly. The disease remission rate in combined nutrition group was 80.0%, better than 76.4% in total enteral nutrition group and 74.5% in total parenteral nutrition group. The morbidity rate was 10.9% in combined nutrition group, and it was lower than that in total enteral nutrition group and total parenteral nutrition group (25.4% and 18.2%, respectively). The length of hospital stay was shorter and the treatment was more cost-effective in combined nutrition group.ConclusionFor patients with Crohn disease, perioperative combined nutritional support is more efficient than total enteral or parental nutrition support.

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