• Neurology · Nov 2005

    Significance of phrenic nerve electrophysiological abnormalities in Guillain-Barré syndrome.

    • M C Durand, H Prigent, V Sivadon-Tardy, D Orlikowski, C Caudie, C Devaux, B Clair, J-L Gaillard, F Lofaso, J-C Raphael, and T Sharshar.
    • Functional Testing Department, Raymond Poincaré Teaching Hospital, Garches, France.
    • Neurology. 2005 Nov 22; 65 (10): 1646-9.

    AbstractThe authors investigated whether the amplitude and latency of diaphragm compound muscle action potential helped predict respiratory failure in Guillain-Barré syndrome. Both variables were significantly but weakly correlated with vital capacity (VC) and were similar in unventilated (n = 60) and ventilated (n = 10) patients. In ventilated patients, motor loss severity, progression, and VC reduction were significantly greater, and bulbar dysfunction was more common. Predicting respiratory failure must rely on clinical features and VC.

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