• Am. J. Physiol. Heart Circ. Physiol. · Nov 2002

    Right ventricular diastolic function in canine models of pressure overload, volume overload, and ischemia.

    • Ares Pasipoularides, Ming Shu, Ashish Shah, Scott Silvestry, and Donald D Glower.
    • Division of Cardiothoracic Surgery, Department of Surgery, Duke University Medical Center, Durham, NC 27710, USA.
    • Am. J. Physiol. Heart Circ. Physiol. 2002 Nov 1; 283 (5): H2140-50.

    AbstractBy limiting filling, abnormalities of right ventricular (RV) diastolic function may impair systolic function and affect adaptation to disease. To quantify diastolic RV pressure-volume relations and myocardial compliance (MC), a new sigmoidal model was developed. RV micromanometric and sonomicrometric data in alert dogs at control (n = 16) and under surgically induced subacute (2-5 wk) RV pressure overload (n = 6), volume overload (n = 7), and ischemia (n = 6) were analyzed. The conventional exponential model detected no changes from control in the passive filling pressure-volume (P(pf)-V) relations. The new sigmoidal model revealed significant quantifiable changes in P(pf)-V relations. Maximum RV MC (MC(max)), attained during early filling, is reduced from control in pressure overload (P = 0.0016), whereas filling pressure at maximum MC (P(MCmax)) is increased (P = 0.0001). End-diastolic RV MC increases significantly in volume overload (P = 0.0131), whereas end-diastolic pressure is unchanged. In ischemia, MC(max) is decreased (P = 0.0102), with no change in P(MCmax). We conclude that the sigmoidal model quantifies important changes in RV diastolic function in alert dog models of pressure overload, volume overload, and ischemia.

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