• J. Am. Coll. Cardiol. · Dec 2006

    Role of Purkinje fibers in post-infarction ventricular tachycardia.

    • Frank Bogun, Eric Good, Stephen Reich, Darryl Elmouchi, Petar Igic, David Tschopp, Sujoya Dey, Alan Wimmer, Krit Jongnarangsin, Hakan Oral, Aman Chugh, Frank Pelosi, and Fred Morady.
    • University of Michigan Medical Center, Ann Arbor, Michigan, USA. fbogun@umich.edu
    • J. Am. Coll. Cardiol. 2006 Dec 19; 48 (12): 2500-7.

    ObjectivesThe objective of this study was to assess the role of Purkinje fibers in monomorphic, post-infarction ventricular tachycardia (VT).BackgroundVentricular fibrillation and polymorphic VT in the setting of acute myocardial infarction (MI) may be triggered by ectopy arising from Purkinje fibers.MethodsFrom among a group of 81 consecutive patients with post-infarction monomorphic VT referred for catheter ablation, 9 patients were identified in whom the clinical VT had a QRS duration < or =145 ms. Mapping was performed focusing on areas with Purkinje potentials.ResultsA total of 11 VTs with a QRS duration < or =145 ms were induced and mapped in the 9 patients; 9 of the 11 VTs had a right bundle branch block/left-axis morphology that mimicked left posterior fascicular VT. The mean VT cycle length was 402 +/- 82 ms. Eight of 9 patients had a history of inferior MI involving the left ventricular septum. One patient had an anterior wall MI with septal involvement. Mapping during VT demonstrated re-entry involving the inferior left ventricular wall. In each of the VTs, a Purkinje potential was present at the exit site of the VT re-entry circuit. Single radiofrequency catheter ablation lesions were successful in eliminating these VTs in all patients.ConclusionsThe Purkinje system may be part of the re-entry circuit in patients with post-infarction monomorphic VT, resulting in a type of VT with a relatively narrow QRS complex that mimics fascicular VT.

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