• Graziella Bruno, Gabriella Gruden, Federica Barutta, Paolo Cavallo Perin, Mario Morino, and Mauro Toppino.
• Department of Medical Sciences, University of Turin, Turin, Italy. Electronic address: graziella.bruno@unito.it.
• Surg Obes Relat Dis. 2015 Sep 1; 11 (5): 1014-9.

BackgroundEffectiveness of sleeve gastrectomy and gastric bypass on glycemic, blood pressure, and lipids control in obese type 2 diabetic patients is poorly known.ObjectiveTo assess the effectiveness of bariatric surgery on obese patients with type 2 diabetes.SettingUniversity hospital, Italy.MethodsDiabetes remission and metabolic changes over postoperative follow-up were assessed in 135 obese patients with type 2 diabetes who underwent bariatric surgery in 2007-2011 (gastric bypass, n = 100; sleeve gastrectomy, n = 35). Repeated-measures analysis of variance and logistic regression were used.ResultsDiabetes remission was observed in 22% and 21.5% of the patients, respectively, 1 and 2 years after surgery. Compared with the remaining patients, patients in diabetes remission were significantly younger, had lower diabetes duration, hemoglobin A1c (HbA1c), fasting plasma glucose, and frequency of insulin treatment. Trends of HbA1c, body mass index (BMI), blood pressure, and plasma triglycerides revealed a significant decrease over time and the trend of HDL-cholesterol revealed a significant increase over time in both treatment groups (P<.001). Patients reaching target levels for at least 3 out of 5 indicators of intermediate outcomes of care (composite indicator of good diabetes control) were 25.5% at the baseline and 66.1% at final follow-up visit (P<.001). In logistic regression, age (OR = .89, 95% CI .84-.95), HbA1c (OR = .67, 95% CI .49-0.91) and diabetes duration (OR = .87, 95% CI .77-1.00) were independent predictors of diabetes remission.ConclusionsBariatric surgery is an effective approach to optimize glucose, lipids, and blood pressure control in obese type 2 diabetic patients. Bariatric surgery should be offered earlier over the natural course of diabetes to increase the likelihood of diabetes remission in obese patients.Copyright © 2015 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

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