• B Degano, F Perrin, T Soumagne, C Agard, A Chambellan, and Groupe Fonction de la SPLF.
• Physiologie-explorations fonctionnelles, EA 3920, hôpital Jean-Minjoz, CHU de Besançon, 25030 Besançon cedex, France. Electronic address: bruno.degano@univ-fcomte.fr.
• Rev Med Interne. 2014 May 1; 35 (5): 322-7.

AbstractDiseases affecting the alveolar-capillary membrane or the capillary blood vessels can impair pulmonary gas exchanges and lung diffusion. The single-breath transfer factor of the lung for carbon monoxide (TL,CO) is the classical technique for measuring gas transfer from the alveolus to the pulmonary capillary blood. Pulmonary gas exchanges can also be explored by the transfer factor of the lung for nitric oxide (TL,NO). TL,NO represents a better index for the diffusing capacity of the alveolar-capillary membrane whereas TL,CO is more influenced by red blood cell resistance. Membrane diffusing capacity (DM) and pulmonary capillary blood volume (Vc) derivated from TL,CO and TL,NO by the Roughton-Forster equation can give additional insights into pulmonary pathologies. The clinical impact of the CO/NO transfer has still to be precised even if this measurement seems to provide an alternative way of investigating the alveolar membrane and the blood reacting with the gas. Copyright © 2013 Société nationale française de médecine interne (SNFMI). Published by Elsevier SAS. All rights reserved.

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