• J. Trop. Pediatr. · Feb 2017

    Randomized Controlled Trial Comparative Study

    Comparison of the Efficacy of Oral 25% Glucose with Oral 24% Sucrose for Pain Relief during Heel Lance in Preterm Neonates: A Double Blind Randomized Controlled Trial.

    • Sweta Kumari, Vikram Datta, and Harmeet Rehan.
    • Department of Pediatrics, Lady Hardinge Medical College, New Delhi 110001, India.
    • J. Trop. Pediatr. 2017 Feb 1; 63 (1): 30-35.

    AimTo study the analgesic effect of oral 25% glucose as compared with oral 24% sucrose during heel lance in preterm neonates.MethodsStable preterm neonates within first 48 hours of life were randomized to receive either 24% sucrose or 25% glucose before heel lance. Primary outcome assessed was painful response by the Premature Infant Pain Profile (PIPP) score at 30 seconds after heel lance, and the secondary outcome was immediate adverse events associated with the administration of two solutions and duration of crying immediately following the procedure.ResultsA total of 94 neonates were randomly assigned into 24% sucrose and 25% glucose group. The baseline characteristics between the two groups were comparable. No significant difference was observed between the two study groups with respect to PIPP scores, duration of crying and rate of adverse events.ConclusionsWhen assessed by PIPP score, 25% glucose and 24% sucrose provided comparable analgesia during heel lance in preterm neonates.© The Author [2016]. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

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