• Marcel du Moulin, Karin Taube, Karl Wegscheider, Michaela Behnke, and Hendrik van den Bussche.
• Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. mmoulin@uke.uni-hamburg.de
• Respiration. 2009 Jan 1; 77 (2): 139-45.

BackgroundPulmonary rehabilitation is successful in improving exercise capacity and quality of life in patients with chronic obstructive pulmonary disease (COPD). However, training effects diminish over time.ObjectivesWe evaluated the effects of simple, daily, structured, self-monitored, home-based exercise training for patients with moderate COPD after a 3-week outpatient rehabilitation.MethodsWe conducted a randomized, controlled, observer-blind trial. Twenty patients were recruited. Ten patients performed home-based exercise training (mean age 67 years, 95% confidence interval [CI] 63-72; FEV(1) 58.6%, 95% CI 53.8-63.4), and 10 patients served as controls (mean age 72 years, 95% CI 69-77; FEV(1) 62.5%, 95% CI 57.7-67.3). At baseline, and after 3 and 6 months, we assessed exercise capacity (6-min walk test, 6MWT, primary endpoint), health-related quality of life (Chronic Respiratory Questionnaire, CRQ) and lung function. An intention-to-treat analysis was performed using two-way ANOVA models for comparison of time trends between random groups.ResultsThe training group had better results than the control group in 6MWT (p = 0.033), in CRQ total (p = 0.027), CRQ dyspnea (p = 0.014) and CRQ fatigue (p = 0.016). Improvement in FEV(1) was also better in the intervention group than in the control group (p = 0.007).ConclusionsWe demonstrated that training effects obtained from an outpatient rehabilitation program can be maintained by home-based exercise training in patients with moderate COPD.2008 S. Karger AG, Basel.

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