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IEEE Trans Biomed Eng · Feb 2007
Multisite recording of extracellular potentials produced by microchannel-confined neurons in-vitro.
- E Claverol-Tinturé, J Cabestany, and X Rosell.
- Department of Electronics, Technical University of Catalonia, Barcelona 08028, Spain. ectmail@eel.upc.edu
- IEEE Trans Biomed Eng. 2007 Feb 1; 54 (2): 331-5.
AbstractTowards establishing electrical interfaces with patterned in vitro neurons, we have previously described the fabrication of hybrid elastomer-glass devices polymer-on-multielectrode array technology and obtained single-electrode recordings of extracellular potentials from confined neurons (Claverol-Tinturé et al., 2005). Here, we demonstrate the feasibility of spatially localized multisite recordings from individual microchannel-guided neurites extending from microwell-confined somas with good signal-to-noise ratios (20 dB) and spike magnitudes of up to 300 microV. Single-cell current source density (scCSD) analysis of the spatio-temporal patterns of membrane currents along individual processes is illustrated.
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