• Clin Toxicol (Phila) · Jan 2012

    Case Reports

    Intravenous paracetamol toxicity in a malnourished child.

    • Ingrid Berling, Michael Anscombe, and Geoffrey K Isbister.
    • Discipline of Clinical Pharmacology, Clinical Toxicology and Pharmacology, Calvary Mater Newcastle, Newcastle, Australia. ingrid.berling@gmail.com
    • Clin Toxicol (Phila). 2012 Jan 1; 50 (1): 74-6.

    AbstractWe present a case of intravenous (IV) paracetamol overdose in a nutritionally malnourished child during hospital admission. A ten-fold IV paracetamol dosing error ocurred, with delayed recognition and treatment resulting in transient hepatotoxicity, with a peak alanine transaminase (ALT) of 1378 IU/L in a 3-year-old child. Our case suggests that hepatotoxicity may occur for lower doses of IV paracetamol compared to oral ingestion, especially in the malnourished, and that a dose less than 150 mg/kg of IV paracetamol should be used to define treatment following overdose in a child with potential nutritional deficiencies.

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