• Vaccine · Sep 2007

    Monitoring of adverse events during the 2003 mass vaccination campaign with a trivalent meningococcal A/C/W135 polysaccharide vaccine in Burkina Faso.

    • Adwoa D Bentsi-Enchill, Issaka Zongo, Selma Khamassi, Robert Pless, Rigobert Thombiano, Sylvestre Tiéndrebéogo, Christopher B Nelson, and Philippe Duclos.
    • World Health Organization, 20 Avenue Appia, CH-1211 Geneva 27, Switzerland. bentsienchilla@who.int
    • Vaccine. 2007 Sep 3; 25 Suppl 1: A72-8.

    AbstractDuring a mass campaign with a newly licensed meningococcal polysaccharide ACW135 vaccine in Burkina Faso, adverse events following immunization (AEFI) were monitored up to 4 weeks after the campaign. Eighty-six AEFI cases (5.9 cases per 100,000 vaccine doses distributed) were reported. Among 22 serious events, 4 severe local reactions were considered very likely and 4 severe allergic reactions were considered probably related to the vaccination. One fatal case in a child followed protracted seizures of undetermined cause. In a setting with no prior surveillance system, adverse events were reported at rates comparable to documented rates for meningococcal polysaccharide vaccines in other settings. The findings confirm the benefits of the vaccine in the control of meningococcal meningitis.

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