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Drug development research · Aug 2020
COVID-19 treatment by repurposing drugs until the vaccine is in sight.
- Mrudula Phadke and Sujata Saunik.
- NHM, Government of Maharashtra, UNICEF, Maharashtra University of Health Sciences, Nashik, Maharashtra, India.
- Drug Dev. Res. 2020 Aug 1; 81 (5): 541-543.
AbstractCorona virus disease (COVID-19) has created pandemic in the world as declared by WHO on March 12, 2020. It is a viral disease caused by SARS-CoV 2 virus and has affected large populations in over 120 countries. There is no specific treatment available and management is empirical. Until such time that an effective vaccine is available for COVID-19 viral infection, one can repurpose known therapeutic drug molecules such as angiotensin receptor 2 blocker, a commonly used antihypertensive drug, to control COVID-19 virus from gaining entry into the host cell by blocking the angiotensin receptor. Clinical trials should also be undertaken to use statins, which are lipid-lowering drugs but have anti-inflammatory and immunomodulatory properties to prevent acute lung injury in COVID-19 infection.© 2020 Wiley Periodicals, Inc.
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