• Surgical infections · Dec 2014

    Case Reports

    Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection.

    • Erlangga Yusuf, Nancy Perrottet, Christina Orasch, Olivier Borens, and Andrej Trampuz.
    • 1 Infectious Diseases Service, Department of Medicine, Lausanne University Hospital , Lausanne, Switzerland .
    • Surg Infect (Larchmt). 2014 Dec 1; 15 (6): 834-7.

    BackgroundDaptomycin is used increasingly to treat prosthetic joint infection (PJI). A possible side effect of this drug is eosinophilic pneumonia. We describe two patients with PJI treated with daptomycin who had this side effect with different clinical presentations.MethodsCase reports and review of the literature.ResultsThe first case was a 64-year-old male who received daptomycin as a part of the treatment for PJI caused by methicillin-resistant Staphylococcus epidermidis (MRSE). He developed fever without other symptoms; bronchoalveolar lavage (BAL) revealed eosinophils. The second was a 61-year-old male who also used daptomycin as part of the treatment of PJI caused by MRSE and developed severe lung symptoms. Bronchoalveolar lavage and pleural fluid showed an increased number of eosinophils.ConclusionDaptomycin-induced pneumonia can present with a wide range of symptoms, from fever alone to severe lung symptoms. Surgeons should be aware of this possible side effect when prescribing daptomycin.

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