• R E Melo, D Solé, and C K Naspitz.
• Department of Pediatrics, Escola Paulista de Medicina, Federal University of São Paulo, Brasil.
• J. Allergy Clin. Immunol. 1997 Feb 1; 99 (2): 204-9.

BackgroundInhaled furosemide has been shown, in patients with asthma, to have prophylactic properties similar to those of disodium cromoglycate.ObjectiveThe aim of this study was to evaluate the protective effect of these drugs in the treatment of exercise-induced asthma.MethodsFifteen children with exercise-induced asthma (mean age, 10.8 years) underwent exercise challenge after a single dose of nebulized placebo, furosemide (20 mg/m7 body area), or disodium cromoglycate (20 mg), 2 days apart, in a single-blind crossover trial.ResultsBoth furosemide and disodium cromoglycate exerted significant protection against the bronchial response to exercise challenge, with a mean maximum percentage falls in FEV1 of 4.66% and 7.22%, respectively (p < 0.05). On the placebo day, the mean maximum percentage fall in FEV1 was 34.50% (p < 0.05).ConclusionThe results of this study suggest that furosemide and disodium cromoglycate provide comparable efficacy in preventing exercise-induced asthma in children, with no side effects.

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