• P Munyard, K F Chung, and A Bush.
• Department of Paediatrics, National Heart and Lung Institute, London, UK.
• Thorax. 1995 Jun 1; 50 (6): 677-9.

BackgroundNebulised frusemide has been shown to be protective against bronchoconstricting stimuli in adult asthmatic subjects and against cold air challenge in children. Animal studies suggest that inhaled frusemide may be more effective in the young.MethodsA double blind placebo, controlled, crossover study on the effect on exercise of pretreatment with frusemide (20 mg) from a metered dose inhaler via a large volume spacer (Volumatic) was performed in 12 asthmatic children. Exercise testing consisted of eight minutes of running on a treadmill in an environmentally controlled laboratory.ResultsDeterioration in lung function was less after frusemide than after the placebo exercise tests. The mean (95% CI) maximum percentage falls in forced expiratory volume in one second (FEV1) were 14.4% (7.7 to 21.0) for placebo and 5.7% (2.3 to 9.0) for frusemide.ConclusionsInhaled frusemide via a metered dose inhaler reduces exercise-induced bronchoconstriction in children.

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