• Internal medicine · Nov 2021

    Case Reports

    A Case of Streptococcal Toxic Shock Syndrome Induced by Group A Streptococcus with the emm28 Genotype that Developed after a Uterine Cancer Test.

    • Yusuke Yamaba, Osamu Takakuwa, Chiaki Ida, Manami Saito, Daisuke Kawae, Misuzu Yoshihara, Eiji Kunii, Kenro Imaeda, Ichiro Tatsuno, Tadao Hasegawa, and Kenji Akita.
    • Department of Respiratory Medicine, Nagoya City University West Medical Center, Japan.
    • Intern. Med. 2021 Nov 1; 60 (21): 3481-3483.

    AbstractA 69-year-old woman without pre-existing disease visited our hospital due to general malaise, diarrhea, and arthralgia 3 days after a uterine cancer test. We diagnosed her with sepsis of unknown focus and started treatment immediately, but she died 20 hours after the first visit due to multi-organ failure and septic shock. Later, group A streptococcus was detected from the blood culture, and streptococcal toxic shock syndrome (STSS) was diagnosed. The strain had the emm28 genotype and a mutation in csrR with increased NADase activity. These virulence factors were considered to be related to STSS development in this patient.

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