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- Shunsuke Sato, Hironori Tsuzura, Yuji Kita, Yuji Ikeda, Daishi Kabemura, Sho Sato, Nozomi Amano, Noboru Yatagai, Ayato Murata, Yuji Shimada, and Takuya Genda.
- Department of Gastroenterology and Hepatology, Juntendo University Shizuoka Hospital, Japan.
- Intern. Med. 2021 Nov 15; 60 (22): 3569-3572.
AbstractDirect-acting antiviral (DAA) therapy carries a potential risk of inducing hepatitis B virus (HBV) reactivation. However, the HBV kinetics during and after DAA therapy in patients co-infected with hepatitis C virus (HCV) and HBV remain unknown. We retrospectively evaluated the HBV kinetics during and after sofosbuvir/ribavirin therapy in four HBV inactive carriers co-infected with HCV. HCV was eradicated in all patients. Changes in HBV-DNA levels during treatment differed among patients. The hepatitis B surface antigen (HBsAg) levels uniformly decreased (mean -0.530 logIU/mL) by the end of treatment and returned to near the baseline in all patients. Sofosbuvir/ribavirin therapy thus demonstrated a suppressive effect on HBsAg.
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