• Expert Rev Clin Pharmacol · Nov 2016

    Review

    Allergen immunotherapy (AIT) for the multiple-pollen sensitive patient.

    • Harold S Nelson.
    • a Department of Medicine , National Jewish Health , Denver , CO , USA.
    • Expert Rev Clin Pharmacol. 2016 Nov 1; 9 (11): 1443-1451.

    IntroductionThe majority of allergic subjects are polysensitized. In Europe, allergy immunotherapy (AIT) in these patients is usually limited to their single clinically most troublesome allergy while in the U.S. the immunotherapy prescription usually includes all allergen extracts to which the patient has evidence of clinical sensitivity. Areas covered: This article will review the evidence supporting the U.S. practice. It will also review the major new development in the management of polysensitized patients, the introduction of component-resolved diagnosis (CRD). Expert commentary: This allows, in many cases, distinguishing in polysensitized patients between sensitization to the major allergens of several unrelated allergen extracts and to panallergens that cause broad patterns of cross-reactivity.

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