• Giorgio Ciprandi, Cristoforo Incorvaia, Franco Frati, and Italian Study Group on Polysensitization.
• IRCCS-AOU San Martino di Genova, Genoa, Italy.
• Expert Rev Clin Immunol. 2015 Jan 1; 11 (9): 973-6.

AbstractA panel of Italian allergists gathered to discuss the issue concerning the management of polysensitized patients. The main conclusions were as follows: polysensitization is a relevant clinical characteristic as it affects about 70-80% of the global allergic population; the diagnostic pathway needs the use of an adequate and thorough methodology, based on the demonstration of consistency between history and documented sensitization; polysensitization and polyallergy are not synonymous: true allergy should always be demonstrated; polysensitization does not constitute a limitation to allergen immunotherapy prescription, as 1-2 allergen extracts could be effective in polysensitized patients; the allergen immunotherapy product characteristics should include the following: high efficacy and optimal safety profile, standardized production, and documented presence and titration of the major allergen.

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