• J Ethnopharmacol · Jul 1988

    Evaluation of the efficacy of Melothria maderaspatana in the alleviation of carbon tetrachloride-induced liver dysfunction.

    • M I Thabrew, K A Jayatilaka, and D J Perera.
    • Department of Biochemistry, Faculty of Medicine, University of Ruhuna, Galle, Sri Lanka.
    • J Ethnopharmacol. 1988 Jul 1; 23 (2-3): 305-12.

    AbstractAn investigation was carried out to evaluate the ability of Melothria maderaspatana to protect the livers of albino rats from carbon tetrachloride-mediated alterations in liver histopathology and serum levels of alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. Treatment with an aqueous extract of Melothria aerial parts (either before or after CCl4 administration) markedly decreased CCl4-mediated alterations in liver histopathology as well as serum enzyme levels. Results provide supportive evidence for the folklore view that this plant is a good hepatotonic.

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