• Eur. J. Clin. Pharmacol. · Aug 2010

    Case Reports Comparative Study

    Pancytopenia due to proguanil toxicity in a returning traveller with fever.

    • Hetty Jolink, Jan den Hartigh, Leo G Visser, and Cees van Nieuwkoop.
    • Department of Infectious Diseases, Leiden University Medical Center, Leiden, the Netherlands. h.jolink@lumc.nl
    • Eur. J. Clin. Pharmacol. 2010 Aug 1; 66 (8): 811-2.

    AbstractA patient known to have renal insufficiency was admitted to the hospital with fever and pancytopenia after returning from a trip to Mali. Pancytopenia was not caused by a tropical infection but was a side effect of atovaquone/proguanil used as malaria chemoprophylaxis. High and prolonged detectable proguanil serum levels can result in bone marrow suppression in patients with renal insufficiency. This should be taken into account in a returning traveller with fever and pancytopenia.

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