• Hepato Gastroenterol · Nov 2003

    Significance of inflammatory cytokines in the progression of colorectal cancer.

    • Yuan-Chang Chung and Ya-Fen Chang.
    • Department of Surgery, Hsin-Chu Hospital, Department of Health, No. 25, Lane 442, Sec 1, Xhing-Kuo Road, Hsin-Chu City, Taiwan, ROC. young@hch.gov.tw
    • Hepato Gastroenterol. 2003 Nov 1; 50 (54): 1910-3.

    Background/AimsCirculating levels of inflammatory cytokines are associated with the disease status of cancer patients. Our purpose was to determine whether the profile of serum levels of interleukin-1 -2, -6, and -8, and tumor necrosis factor in patients with colorectal cancer correlated with tumor stages and survival.MethodologySerum concentrations of individual cytokines in 164 colorectal cancer patients were determined before operation by enzyme-linked immunosorbent assay. The clinical significance of each serum cytokine was evaluated in relation to tumor progression and survival.ResultsLevels of interleukin-6 and interleukin-8 were significantly higher in patients than in controls. The serum concentrations of interleukin-2 and interleukin-6 were correlated with Dukes' stages. Only the levels of interleukin-6 were found to be associated with patient survival by univariate analysis. However, multivariate analysis did not identify interleukin-6 level as an independent factor of prognosis.ConclusionsElevation of serum cytokines, such as interleukin-6, may be related to the development and progression of colorectal cancer. Interleukin-6 level is associated with the clinical outcome, but is not an effective prognostic predictor.

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