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Modern rheumatology · Dec 2011
Case ReportsInduction of clinical remission with adalimumab-methotrexate combination therapy in a patient with rheumatoid arthritis and concomitant hepatitis C virus infection.
- Osamu Noguchi and Yukio Gibo.
- Department of Rheumatology, Gennoki Clinic, 2680-1 Nishiharuchika, Ina, Nagano 399-4431, Japan. gennoki@inacatv.ne.jp
- Mod Rheumatol. 2011 Dec 1; 21 (6): 696-700.
AbstractThe patient described here is a 49-year-old woman who had hepatitis C virus (HCV) infection and rheumatoid arthritis (RA). Her RA had been successfully managed with methotrexate for about 10 years. After a sustained virological response was achieved with interferon therapy, treatment with adalimumab was instituted. This resulted in a rapid and sustained remission that lasted for more than a year, without HCV reactivation. The results in this case suggest that a sequential strategy, with initial HCV clearance followed by the targeting of remission with biologics, may be a favorable option in patients with RA and concomitant HCV infection.
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