• Sheng-Chieh Chou, Chen-Hsueh Pai, Shu-Wha Lin, and Hwei-Fang Tien.
• Division of Hematology, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: choushengchieh@ntuh.gov.tw.
• J Formos Med Assoc. 2022 Jan 1; 121 (1 Pt 2): 360-366.

BackgroundCancer-associated venous thromboembolism (VTE) is a distinct pathological entity with much higher incidence and unique risk factors compared to general VTE. A previous study reported that cancer associated-VTE incidence in Taiwan is much lower than that reported for western countries and also lower than our anecdotal observations. To address this issue further, we initiated an investigation locally using a more detailed approach than used previously with comprehensive review of medical records to gain new insight into the incidence and risk factors for cancer-associated VTE.MethodsMedical records of all adult patients with lung, pancreatic and gastric cancers, and lymphoma diagnosed from January 2011 to December 2013 in National Taiwan University Hospital indexed through the local cancer registry database were reviewed. VTE patients were identified through diagnosis coding and comprehensive medical chart review.ResultsAmong 5620 consecutive lung, gastric and pancreatic cancer, and lymphoma patients, VTE was diagnosed in 246 (4.4%). Overall VTE incidence was 36.3 per 1000 patient-year. Multivariate analysis showed that not only high but also low body mass index (BMI) was associated with VTE risk with different cutoff levels by gender. Mildly to moderately anemic patients were at higher risk of VTE. Activated partial thromboplastin time (aPTT) had proportionally and reversely correlation to VTE risk.ConclusionWe reported higher incidence of cancer associated VTE in Taiwan. Low BMI and short aPTT were found to be related to higher VTE risk that was not reported before.Copyright © 2021 Formosan Medical Association. Published by Elsevier B.V. All rights reserved.

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