• Camille E van Hoorn, van der Cammen-van ZijpMonique H MMHM0000-0001-8495-4634Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.Department of Orthopedics, Section of Physical therapy, Erasmus, Robert Jan Stolker, Joost van Rosmalen, WijnenRene M HRMH0000-0001-7266-9713Department of Pediatric Surgery, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands., and Jurgen C de Graaff.
• Department of Anesthesia, Erasmus MC-Sophia Children's Hospital, University Medical Center Rotterdam, Rotterdam, The Netherlands.
• Paediatr Anaesth. 2021 Aug 1; 31 (8): 854-862.

BackgroundChildren born with esophageal atresia experience long-term neurodevelopmental deficits, with unknown origin.AimsTo find associations between perioperative variables during primary esophageal atresia repair and motor function at age 5 years.MethodsThis ambidirectional cohort study included children born with esophageal atresia who consecutively had been operated on in the Erasmus MC-Sophia Children's Hospital, University Medical Center, Rotterdam, from January 2007 through June 2013. The perioperative data of this cohort were collected retrospectively; the motor function data prospectively.ResultsAfter exclusion of patients with syndromal congenital diseases (n = 8) and lost to follow-up (n = 10), the data of 53 children were included. The mean (SD) total motor function impairment z-score at 5 years of age was -0.66 (0.99), significantly below normal (p < .001). In multivariable linear regression analysis, number of postoperative days endotracheal intubation (B = -0.211, 95% CI: -0.389 to -0.033, p = .021) was negatively associated with motor outcome, whereas high blood pressure (B = 0.022, 95% CI 0.001 to 0.042, p = .038) was positively associated. Preoperative nasal oxygen supplementation versus room air (B = 0.706, 95% CI: 0.132 to 1.280, p = .016) was positively associated with motor outcome, which we cannot explain.ConclusionsMotor function in 5-year-old esophageal atresia patients was impaired and negatively associated with the number of postoperative days of endotracheal intubation and positively associated with high blood pressure. Prospective studies with critical perioperative monitoring and monitoring during stay at the intensive care unit are recommended.© 2021 The Authors. Pediatric Anesthesia published by John Wiley & Sons Ltd.

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