• Chest · Apr 2021

    Case Reports

    Midodrine, an Oral Alpha-1 Adrenoreceptor Agonist, Successfully Treated Refractory Congenital Chylous Pleural Effusion and Ascites in a Neonate.

    • Satoshi Tamaoka, Asami Osada, Takane Kin, Takeshi Arimitsu, and Mariko Hida.
    • Department of Pediatrics, Keio University School of Medicine, Shinjuku-ku, Tokyo, Japan. Electronic address: rainbow09tama21@yahoo.co.jp.
    • Chest. 2021 Apr 1; 159 (4): e189-e191.

    AbstractA trisomy 21 neonate presented with congenital chylous pleural effusion and ascites that was refractory to conventional pharmacotherapy. Midodrine, an oral alpha-1-adrenoreceptor agonist, achieved remission of chylous effusion without any adverse effects. To the best of our knowledge, this is the first neonatal case of successful management of congenital chylous pleural effusion and ascites with midodrine.Copyright © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved.

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