• Jacob L Hutchins, David Leiman, Zubaid Rafique, Karen P DiDonato, and Pamela P Palmer.
• Department of Anesthesiology, University of Minnesota, Minneapolis, MN.
• J. Perianesth. Nurs. 2020 Feb 1; 35 (1): 22-28.

PurposeTo aid nurses in dosing sufentanil sublingual tablet (SST) 30 mcg administered via a single-dose applicator, dosing requirements and efficacy of SST 30 mcg were analyzed across age, sex, race, and body mass index subgroups.DesignPatient characteristics were pooled from three postoperative studies (two placebo-controlled and one open-label) and one open-label emergency department study. Drug dosing and efficacy data were pooled from the postoperative studies.MethodsEfficacy was assessed through summed pain intensity difference to baseline during 12 hours across subgroups.FindingsMean (standard deviation) drug doses administered from 0 to 12 hours was 3.9 (2.0) for SST 30 mcg and was less frequent for older (≥65 years) versus younger patients. The summed pain intensity difference to baseline during 12 hours was superior with SST 30 mcg versus placebo across all subgroups.ConclusionsSST 30 mcg is a sublingual opioid analgesic with efficacy across demographic subgroups.Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

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