• Eurosurveillance · May 2018

    Case Reports

    Multidrug-resistant Neisseria gonorrhoeae failing treatment with ceftriaxone and doxycycline in France, November 2017.

    • Thibault Poncin, Sebastien Fouere, Aymeric Braille, Francois Camelena, Myriem Agsous, Cecile Bebear, Sylvain Kumanski, Florence Lot, Severine Mercier-Delarue, Ndeindo Ndeikoundam Ngangro, Maud Salmona, Nathalie Schnepf, Julie Timsit, Magnus Unemo, and Beatrice Bercot.
    • French National Reference Center for bacterial STI, Associated laboratory for gonococci, APHP, Paris, France.
    • Eurosurveillance. 2018 May 1; 23 (21).

    AbstractWe report a multidrug-resistant Neisseria gonorrhoeae urogenital and pharyngeal infection with ceftriaxone resistance and intermediate resistance to azithromycin in a heterosexual woman in her 20s in France. Treatment with ceftriaxone plus doxycycline failed for the pharyngeal localisation. Whole-genome sequencing of isolate F90 identified MLST1903, NG-MAST ST3435, NG-STAR233, and relevant resistance determinants. F90 showed phenotypic and genotypic similarities to an internationally spreading multidrug-resistant and ceftriaxone-resistant clone detected in Japan and subsequently in Australia, Canada and Denmark.

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