• Br. J. Haematol. · Oct 2018

    Meta Analysis

    Incidence of intracranial bleeding in anticoagulated patients with minor head injury: a systematic review and meta-analysis of prospective studies.

    • Hersimren Minhas, Arthur Welsher, Michelle Turcotte, Michelle Eventov, Suzanne Mason, Daniel K Nishijima, Grégoire Versmée, Meirui Li, and de Wit Kerstin K 0000-0003-2763-6474 Divisions of Emergency Medicine and Hematology, McMaster University, Hamilton, ON, Canada..
    • Chicago Medical School, Rosalind Franklin University, North Chicago, IL, USA.
    • Br. J. Haematol. 2018 Oct 1; 183 (1): 119-126.

    AbstractGuidelines advise performing a computed tomography head scan for all anticoagulated head injured patients, but the risk of intracranial haemorrhage (ICH) after a minor head injury is unclear. We conducted a systematic review and meta-analysis to determine the incidence of ICH in anticoagulated patients presenting with a minor head injury and a Glasgow Coma Score (GCS) of 15. We followed Meta-Analyses and Systematic Reviews of Observational Studies guidelines. We included all prospective studies recruiting consecutive anticoagulated emergency patients presenting with a head injury. Anticoagulation included vitamin-K antagonists (warfarin, fluindione), direct oral anticoagulants (apixaban, rivaroxaban, dabigatran and edoxaban) and low molecular weight heparin. A total of five studies (including 4080 anticoagulated patients with a GCS of 15) were included in the analysis. The majority of patients took vitamin K antagonists (98·3%). There was significant heterogeneity between studies with regards to mechanism of injury and methods. The random effects pooled incidence of ICH was 8·9% (95% confidence interval 5·0-13·8%). In conclusion, around 9% of patients on vitamin K antagonists with a minor head injury develop ICH. There is little data on the risk of traumatic intracranial bleeding in patients who have a GSC 15 post-head injury and are prescribed a direct oral anticoagulant.© 2018 British Society for Haematology and John Wiley & Sons Ltd.

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