• Reprod Biol Endocrin · May 2021

    Observational Study

    Does mRNA SARS-CoV-2 vaccine influence patients' performance during IVF-ET cycle?

    • Raoul Orvieto, Meirav Noach-Hirsh, Aliza Segev-Zahav, Jigal Haas, Ravit Nahum, and Adva Aizer.
    • Department of Obstetrics and Gynecology, Chaim Sheba Medical Center (Tel Hashomer), Ramat Gan, Israel. raoul.orvieto@sheba.health.gov.il.
    • Reprod Biol Endocrin. 2021 May 13; 19 (1): 69.

    ObjectiveNo information exists in the literature regarding the effect of mRNA SARS-CoV-2 vaccine on subsequent IVF cycle attempt. We therefore aim to assess the influence of mRNA SARS-CoV-2 vaccine on IVF treatments.DesignAn observational study.SettingA tertiary, university-affiliated medical center.Patients And MethodsAll couples undergoing consecutive ovarian stimulation cycles for IVF before and after receiving mRNA SARS-CoV-2 vaccine, and reached the ovum pick-up (OPU) stage. The stimulation characteristics and embryological variables of couples undergoing IVF treatments after receiving mRNA SARS-CoV-2 vaccine were assessed and compared to their IVF cycles prior to vaccination.Main Outcome MeasuresStimulation characteristics and embryological variables.ResultsThirty-six couples resumed IVF treatment 7-85 days after receiving mRNA SARS-CoV-2 vaccine. No in-between cycles differences were observed in ovarian stimulation and embryological variables before and after receiving mRNA SARS-CoV-2 vaccination.ConclusionsmRNA SARS-CoV-2 vaccine did not affect patients' performance or ovarian reserve in their immediate subsequent IVF cycle. Future larger studies with longer follow-up will be needed to validate our observations.

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