• Bull NYU Hosp Jt Dis · Jan 2010

    Review

    Fibromyalgia: knowns, unknowns, and current treatment.

    • Bruce M Solitar.
    • New York University School of Medicine, Hospital for Joint Diseases, New York, New York 10016, USA. brucesol@verizon.net
    • Bull NYU Hosp Jt Dis. 2010 Jan 1; 68 (3): 157-61.

    AbstractFibromyalgia is a chronic syndrome of diffuse musculoskeletal pain with tenderness at specific locations, often associated with persistent fatigue, cognitive and mood disorders, joint stiffness, and insomnia. Understanding the pathophysiology of fibromyalgia and the establishment of effective treatments have been complex endeavors that have not yielded simple answers. Nevertheless, recent studies have shed light on the roles of central pain processing, genetic abnormalities, and external factors on development of the fibromyalgia syndrome (FMS). These findings have led to the use of new therapies that have shown beneficial effects on symptoms. This review discusses ideas that have become accepted as well as novel associations under consideration in regard to the pathogenesis of fibromyalgia and the current and emerging therapeutics for its treatment.

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