• Respir Physiol Neurobiol · Apr 2005

    Comparative Study Clinical Trial

    Cough determinants in patients with neuromuscular disease.

    • Grégoire Trebbia, Mathieu Lacombe, Christophe Fermanian, Line Falaize, Michèle Lejaille, Alain Louis, Christian Devaux, Jean Claude Raphaël, and Frédéric Lofaso.
    • Medical Intensive Care Unit, Physiology and Function Testing Unit/Technological Innovation Center, AP-HP, 92380 Garches, France.
    • Respir Physiol Neurobiol. 2005 Apr 15; 146 (2-3): 291-300.

    AbstractNeuromuscular disease leads to cough impairment. Cough augmentation can be achieved by mechanical insufflation (MI) or manually assisted coughing (MAC). Many studies have compared these two methods, but few have evaluated them in combination. In 155 neuromuscular patients, we assessed determinants of peak cough flow (PCF) using stepwise correlation. Maximal inspiratory capacity contributed 44% of the variance (p<0.001), expiratory reserve volume 13%, and maximal expiratory pressure 2%. Thus, augmenting inspiration seems crucial. However, parameters dependent on expiratory muscles independently influence PCF. We measured vital capacity and PCF in 10 neuromuscular patients during cough augmentation by MI, MAC, or both. MI or MAC significantly improved VC and PCF (p<0.01) as compared to the basal condition and VC and PCF were higher during MI plus MAC than during MAC or MI alone (p<0.01). In conclusion, combining MAC and MI is useful for improving cough in neuromuscular patients.

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