• J. Pediatr. Gastroenterol. Nutr. · Jan 1982

    Randomized Controlled Trial Comparative Study Clinical Trial

    Lubricant versus laxative in the treatment of chronic functional constipation of children: a comparative study.

    • J M Sondheimer and E P Gervaise.
    • J. Pediatr. Gastroenterol. Nutr. 1982 Jan 1; 1 (2): 223-6.

    AbstractThe efficacy of two medications commonly used in treatment of chronic functional constipation of children (CFC) was compared. Thirty-seven children (aged 3-12 years) with typical CFC were assigned at random to treatment with mineral oil or standardized senna concentrate (Senokot). The results of follow-up evaluations at 1, 3, and greater than 6 months indicate that symptom control (fecal soiling and decreased stool frequency) was significantly better in mineral-oil-treated patients. At least one recurrence of symptoms occurred in 66% of mineral-oil-treated and 89% of Senokot-treated patients. However, recurrences appeared later and less frequently in mineral-oil-treated patients. After 6 months, 55% of those treated with mineral oil had successfully discontinued regular medication. After 6 months, only 22% of Senokot-treated patients had successfully discontinued medication, while an additional 33% had stopped taking medication because of poor symptom control.

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