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Modern rheumatology · Feb 2011
Case ReportsSyndrome of inappropriate secretion of antidiuretic hormone induced by tacrolimus in a patient with systemic lupus erythematosus.
- Koichiro Suemori, Hitoshi Hasegawa, Chika Nanba, Masashi Kohno, Takuya Matsumoto, Yusuke Kawamoto, Shinji Murakami, Eiji Sada, Koji Hashimoto, and Masaki Yasukawa.
- Department of Bioregulatory Medicine, Ehime University Graduate School of Medicine, Toon, Ehime, 791-0295, Japan. suemori@m.ehime-u.ac.jp
- Mod Rheumatol. 2011 Feb 1; 21 (1): 97-100.
AbstractWe describe the first reported case of a syndrome of inappropriate secretion of antidiuretic hormone (SIADH) induced by low-dose tacrolimus in a patient with autoimmune disease. A 41-year-old man with systemic lupus erythematosus (SLE) developed hyponatremia induced by SIADH after administration of tacrolimus (0.06 mg/kg per day). In this case, the hyponatremia promptly resolved upon withdrawal of tacrolimus. This case strongly suggests that SIADH is a potentially important complication of tacrolimus administration, irrespective of dosage, and should be borne in mind whenever the drug is used.
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