• Vaccines · Apr 2021

    BNT162b2 Vaccine Encoding the SARS-CoV-2 P2 S Protects Transgenic hACE2 Mice against COVID-19.

    • Rui-Ru Ji, Yajin Qu, Hua Zhu, Yumei Yang, Annette B Vogel, Ugur Sahin, Chuan Qin, and Aimin Hui.
    • Shanghai Fosun Pharmaceutical Industrial Development, Co. Ltd., 1289 Yishan Road, Shanghai 200233, China.
    • Vaccines (Basel). 2021 Apr 1; 9 (4).

    AbstractBNT162b2 is a highly efficacious mRNA vaccine approved to prevent COVID-19. This brief report describes the immunogenicity and anti-viral protective effect of BNT162b2 in hACE2 transgenic mice. Prime-boost immunization with BNT162b2 elicited high titers in neutralizing antibodies against SARS-CoV-2, which correlated with viral clearance and alleviated lung lesions in these mice after viral challenge.

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