• Vaccine · Sep 2011

    Combined protective effects of anti-PhtD and anti-pneumococcal polysaccharides.

    • Philippe Denoël, Fabrice Godfroid, Philippe Hermand, Vincent Verlant, and Jan Poolman.
    • Research & Development, GlaxoSmithKline Biologicals, Rue de l'Institut 89, B-1330 Rixensart, Belgium.
    • Vaccine. 2011 Sep 2; 29 (38): 6451-3.

    AbstractIn the past years, a significant rise in the proportion of childhood complicated pneumonia cases related to pneumococcal serotypes 1 and 3 has been observed. PhtD is a vaccine candidate protein antigen. By using a pneumococcal lethal intranasal challenge mouse model, a significant additive effect on protection was observed with the combination of vaccination-induced anti-PhtD and injected anti-polysaccharide antibodies specific for serotypes 1 and 3.Copyright © 2011 Elsevier Ltd. All rights reserved.

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