• K J Zheng, E Middelkoop, M Stoop, van ZuijlenP P MPPMBurn Centre, Red Cross Hospital, Beverwijk, The Netherlands; Amsterdam UMC, Location VUmc, Department of Plastic, Reconstructive and Hand Surgery, Amsterdam Movement Sciences, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands; Depar, and A Pijpe.
• Burn Centre, Red Cross Hospital, Beverwijk, The Netherlands; Amsterdam UMC, Location AMC, Amsterdam, The Netherlands. Electronic address: kzheng@tergooi.nl.
• Burns. 2022 Mar 1; 48 (2): 319-327.

ObjectiveTo assess validity of Laser Speckle Contrast Imaging (LSCI) for the measurement of burn wound healing potential (HP) in a burn centre patient population, based on Laser Doppler Imaging (LDI) as reference standard.MethodA single-centre prospective observational cohort study was performed between September-December 2019. A total of 50 burns in 14 patients were included. Imaging and data collection were standardized. Correlation between LSCI and LDI flux values was tested. ROC curves were developed to test the discriminative ability of LSCI between LDI HP categories.ResultsNumber of adults and children were equal. Mean total body surface area burnt was 5.5%. Main burn causes were scalds (64%) and flame burns (36%). LSCI set-up and imaging duration was 3 min and 10 s, respectively. LSCI was able to discriminate between wounds with early versus delayed HP (<14 versus ≥14 days) with sensitivity 71% and specificity 95% (p < 0.001). For HP ≤21 versus >21 days, similar sensitivity (74%) and specificity (95%) were found (p < 0.001). Correlations between LSCI and LDI flux values were moderate (<14 days) to absent (>21 days).ConclusionLSCI shows good validity for the prediction of burn wound HP. It is a highly feasible, patient and physician friendly tool.Copyright © 2021 Elsevier Ltd and ISBI. All rights reserved.

16 keywords...

hide…