• Feiri Huang, Zhifang Yang, Zhongliang Su, and Xiaosheng Gao.
• Department of Orthopedics, The Third Clinical Institute Affiliated to Wenzhou Medical University, Wenzhou People's Hospital.
• Medicine (Baltimore). 2021 May 21; 100 (20): e25740e25740.

IntroductionThe efficacy of gabapentin for pain management of arthroscopy remains controversial. We conduct a systematic review and meta-analysis to explore the influence of gabapentin versus placebo on the postoperative pain intensity of arthroscopy.MethodsWe search PubMed, EMbase, Web of science, EBSCO, and Cochrane library databases through April 2020 for randomized controlled trials assessing the effect of gabapentin versus placebo on pain control of arthroscopy. This meta-analysis is performed using the random-effect model.ResultsFive randomized controlled trials are included in the meta-analysis. Overall, compared with control group for arthroscopy, gabapentin remarkably decreases pain scores at 24 hour (standard mean difference [SMD]=-0.68; 95% confidence interval [CI]=-1.15 to -0.02; P = .21), analgesic consumption (SMD = -18.24; 95% CI=-24.61 to -11.88; P < .00001), nausea and vomiting (OR = 0.42; 95% CI = 0.21 to 0.84; P = .01), but has no obvious influence on pain scores at 6 h (SMD = -1.30; 95% CI = -2.92 to 0.31; P = .11) or dizziness (OR = 1.12; 95% CI = 0.56 to 2.24; P = .75).ConclusionsGabapentin is effective for pain control after arthroscopy.Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc.

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