• Alley E Ronaldi, Marta J Madurska, Joseph D Bozzay, Jeanette E Polcz, David G Baer, David M Burmeister, Paul W White, Todd E Rasmussen, and Joseph M White.
• Walter Reed National Military Medical Center, The Uniformed Services University of the Health Sciences, Bethesda, Maryland.
• Shock. 2021 Oct 1; 56 (4): 493506493-506.

AbstractResuscitative endovascular balloon occlusion of the aorta (REBOA) allows for effective temporization of exsanguination from non-compressible hemorrhage (NCTH) below the diaphragm. However, the therapeutic window for aortic occlusion is time-limited given the ischemia-reperfusion injury generated. Significant effort has been put into translational research to develop new strategies to alleviate the ischemia-reperfusion injury and extend the application of endoaortic occlusion. Targeted regional optimization (TRO) is a partial REBOA strategy to augment proximal aortic and cerebral blood flow while targeting minimal threshold of distal perfusion beyond the zone of partial aortic occlusion. The objective of TRO is to reduce the degree of ischemia caused by complete aortic occlusion while providing control of distal hemorrhage. This review provides a synopsis of the concept of TRO, pre-clinical, translational experiences with TRO and early clinical outcomes. Early results from TRO strategies are promising; however, further studies are needed prior to large-scale implementation into clinical practice.Copyright © 2021 by the Shock Society.

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