• A Irizar, F Gil, A Lertxundi, M C Martín-Domingo, N Urbieta, A Molinuevo, J Ibarluzea, M Basterrechea, J J Aurrekoetxea, A Jiménez-Zabala, and L Santa-Marina.
• BIODONOSTIA Health Research Institute, Paseo Dr. Beguiristain, San Sebastian 20014, Spain. Electronic address: a-irizarloibide@euskadi.eus.
• Environ. Res. 2019 Mar 1; 170: 92-100.

AbstractExposure to manganese (Mn) has been associated with neurodevelopmental problems in children. Mn exposure begins in utero, and maternal sociodemographic, dietary and environmental factors may affect Mn levels in newborns' hair. This study aimed to characterize in utero Mn exposure using Mn levels in newborns' hair as a biomarker of prenatal exposure, and to analyze its relationship with sociodemographic, dietary and environmental factors in the Spanish INMA-Gipuzkoa cohort. Overall, 638 pregnant women were recruited in the first trimester of pregnancy and a hair sample was obtained from 473 newborns. Sociodemographic, dietary and environmental data were recorded through two questionnaires administered in the first and third trimesters of pregnancy. The median Mn concentration in newborns´ hair was 0.31 µg/g (P5 = 0.02; P95 = 1.23). Mn levels in newborns´ hair were associated with smoking during pregnancy (β = 0.222; 95% CI = 0.065-0.379) and with maternal PM2.5 exposure (β = 0.025; 95% CI = 0.004; 0.047), as well as with cereal and pasta intake in the first trimester of pregnancy (β = 0.002; 95% CI = 0.0004; 0.003). In conclusion, fetal exposure to Mn was associated with smoking and exposure to atmospheric pollution during pregnancy.Copyright © 2018. Published by Elsevier Inc.

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