• S R Dyer, P J Thottam, S Saraiya, and M Haupert.
• Department of Otolaryngology - Head/Neck Surgery and Facial Plastic Surgery, Children's Hospital of Michigan, Michigan 48067, USA.
• J Laryngol Otol. 2013 Aug 1; 127 (8): 814-6.

IntroductionThe objective of this article was to report a case of isolated, acute, right-sided sphenoid sinusitis that progressed to contralateral cavernous sinus thrombosis in an 18-year-old male patient. We describe the atypical presentation of this case and discuss the relevant anatomy, pathogenesis, presentation, diagnostic evaluation and treatment.Case ReportA case report of sphenoid sinusitis leading to contralateral cavernous sinus thrombosis was reviewed and presented along with a comprehensive literature review of the relevant anatomy, pathophysiology, microbiology, diagnostic work-up and treatment options.ConclusionCavernous sinus thrombosis is a rare clinical entity in the antibiotic era. However, limited sphenoid sinusitis may progress to cavernous sinus thrombosis in spite of maximal medical treatment, as highlighted in this case report. The mainstay of treatment includes early diagnosis allowing aggressive intravenous antibiotics and appropriate surgical management.

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