• Nicola Veronese, Brendon Stubbs, Marco Solmi, Toby O Smith, Marianna Noale, Cyrus Cooper, and Stefania Maggi.
• Department of Medicine (DIMED), Geriatrics Division, University of Padova, Padova, Italy.
• Age Ageing. 2017 May 1; 46 (3): 470-476.

Backgroundosteoarthritis (OA) is associated with a number of medical morbidities. Although the prevalence of depression and depressive symptoms is presumed to be high in people with OA, no prospective comparative study has analyzed its incidence.Objectiveto determine whether OA was associated with an increased odds of developing depressive symptoms.Designlongitudinal cohort study (follow-up: 4.2 years).Settingdata were gathered from the North American Osteoarthritis Initiative (OAI) dataset.Subjectspeople at higher risk developing OA.MethodsOA diagnosis was defined as the presence of OA at hand, knee, hip, back/neck or other sites at baseline. Depressive symptoms were defined using the 20-item Center for Epidemiologic Studies-Depression (cut-off 16 points) after 4 years.Resultsa total of 3,491 people without depressive symptoms at baseline were analyzed (1,506 with OA/1,985 without). Using an adjusted logistic regression analysis for 12 potential confounders, people with OA had a similar odds of depressive symptoms at follow-up compared to those without OA (odds ratio (OR): 1.26; 95% confidence of interval (CI): 0.95-1.67). However, multi-site OA (i.e. OA ≥2 sites; OR: 1.48, 95% CI: 1.07-2.05) and the specific presence of hip (OR: 1.72; 95% CI: 1.08-2.73) or knee OA (OR: 1.43; 95% CI: 1.03-1.98) were associated with a greater odds of developing depressive symptoms compared to people without OA.Conclusionsthis is the first study of longitudinal data to demonstrate people with multi-site, hip or knee OA have a greater odds of developing depressive symptoms compared to people without OA. This suggests that OA may be associated with future mental health burden.© The Author 2016. Published by Oxford University Press on behalf of the British Geriatrics Society. All rights reserved. For permissions, please email: journals.permissions@oup.com

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