• Fu-Cheng Chen, Yan-Ren Lin, Chia-Te Kung, Cheng-I Cheng, and Chao-Jui Li.
• Department of Emergency Medicine, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan.
• Biomed Res Int. 2017 Jan 1; 2017: 1910934.

AbstractBackground. The study aimed to verify the effect of primary percutaneous coronary intervention (PPCI) with <60 min door-to-balloon time on ST segment elevation myocardial infarction (STEMI) patients' prognoses. Methods. Outcomes of patients receiving PPCI with door-to-balloon time of <60 min were compared with those of patients receiving PPCI with door-to-balloon time 60-90 min. Result. Totally, 241 STEMI patients (191 with Killip classes I or II) and 104 (71 with Killip classes I or II) received PPCI with door-to-balloon time <60 and 60-90 min, respectively. Killip classes I and II patients with door-to-balloon time <60 min had better thrombolysis in myocardial infarction (TIMI) flow (9.2% fewer patients with TIMI flow <3, p = 0.019) and 8.0% lower 30-day mortality rate (p < 0.001) than those with 60-90 min. After controlling the confounding factors with logistic regression, patients with door-to-balloon time <60 min had lower incidences of TIMI flow <3 (aOR = 0.4, 95% CI = 0.20-0.76), 30-day recurrent myocardial infarction (aOR = 0.3, 95% CI = 0.10-0.91), and 30-day mortality (aOR = 0.3, 95% CI = 0.09-0.77) than those with 60-90 min. Conclusion. Door-to-balloon time <60 min is associated with better blood flow in the infarct-related artery and lower 30-day recurrent myocardial infarction and 30-day mortality rates.

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