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- Michael Peer, Edina Csaszar, Elisabeth Vorlaufer, Stephan Kopp, and Peter Chiba.
- Department of Medical Chemistry, Medical University of Vienna, Vienna, Austria.
- Mini Rev Med Chem. 2005 Feb 1; 5 (2): 165-72.
AbstractThe aim of the present review is to summarize recent progress in identifying substrate binding domains of P-glycoprotein by photoaffinity labeling. Preferred substrate binding regions have been identified using a number of photoaffinity ligands, including anthracyclines, the quinazoline iodoarylazidoprazosine (IAAP), dihydropyridines, taxanes and propafenones. These studies allowed identification of protein regions, which are involved in ligand interaction.
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