• World J. Gastroenterol. · Mar 2015

    Case Reports

    Complicated fecal microbiota transplantation in a tetraplegic patient with severe Clostridium difficile infection.

    • Thorsten Brechmann, Justyna Swol, Veronika Knop-Hammad, Jörg Willert, Mirko Aach, Oliver Cruciger, Wolff Schmiegel, Thomas A Schildhauer, and Uwe Hamsen.
    • Thorsten Brechmann, Wolff Schmiegel, Jörg Willert, Department of Gastroenterology and Hepatology, Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Ruhr-University Bochum, 44789 Bochum, Germany.
    • World J. Gastroenterol. 2015 Mar 28; 21 (12): 3736-40.

    AbstractA 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile (C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.

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