• Cor et vasa · Jan 1992

    Randomized Controlled Trial Clinical Trial

    The effect of allopurinol on free oxygen radicals in myocardial reperfusion.

    • J Fabián, Z Popovic, and M Vucinic.
    • Postgraduate Medical Institute, Bratislava, Slovak Republic.
    • Cor Vasa. 1992 Jan 1; 34 (5-6): 411-20.

    AbstractThe transmyocardial turnover of lactate, oxidized and reduced glutathione, malondialdehyde, and the isoenzyme CK-MB before and after restoration of myocardial blood flow was studied in 18 patients undergoing coronary artery surgery. Of this number, ten patients were given oral allopurinol preoperatively; the remaining patients made up the control group. Allopurinol significantly reduced the levels of free oxygen radicals. The enzymatic methods employed did not make it possible to evaluate the protective effect of allopurinol on reperfusion myocardial injury.

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